Diablo 4 Season 1 introduced Wrathful Hearts, which give players powerful skills to add to their gear, and one of the most sought-after is the Vile Apothecary Heart.

The Vile Apothecary Heart is a game-changing Rogue skill that gives players a 5-15% chance to apply all Imbuement Effects at 50-60% of their normal potency. This allows players to maximize their damage output and do something they ordinarily wouldn’t be able to.

In this guide, we’ll break down the best farming method to get the Vile Apothecary Heart in Diablo 4.

How to Get Caged Vile Apothecary Heart

To get the Vile Apothecary Heart, you need to find a Wrathful Malignant enemy while playing Diablo 4 Season 1 in World Tier 4 and hope that it drops the Caged Heart of the Vile Apothecary.

Players can also craft a Caged Heart of the Vile Apothecary at Cormond’s Workbench by taking a chance with the Uncertain Heart Cache.

This is completely up to chance; unfortunately, the odds of obtaining a Wrathful Heart are already very low. When you try to focus on just one Wrathful Heart, like the Vile Apothecary Heart, then your odds decrease even more.

However, this doesn’t mean that it’s impossible. Players have found some useful methods to farming Wrathful Hearts that can help increase your odds by a great margin.

  1. Method 1 – Farm the Malignant Tunnels in World Tier 4. These Malignant Tunnels have a high possibility of having Elite Malignant enemies that could potentially drop Wrathful Hearts. This is by far the best method.
    • You can find Malignant Tunnels by searching for a seasonal leaf icon on a dungeon. Below is one of the best ones to use for farming Malignant Hearts.
Bedeviled Grotto Malignant Tunnel Map Icon in Diablo 4
  1. Method 2 – Craft an Uncertain Invoker and hope it gives you a Wrathful Invoker. This will allow you to summon a Wrathful Malignant enemy at a Wrathful Malignant Outgrowth.
  2. Method 3 – Craft an Uncertain Heart Cache for a chance to gain a Caged Vile Apothecary Heart. However, players have noted that the Uncertain Heart Cache has terrible odds when it comes to Wrathful Hearts.
Uncertain Heart Cache Diablo 4

Use these methods to increase your odds of stumbling upon the Caged Vile Apothecary Heart while exploring Sanctuary. Thankfully, if you do find this Caged Heart, you won’t need to worry about which slot to place it in since it can go into any of the Infested Sockets.

How to Craft Caged Heart of the Vile Apothecary

Players have the chance to craft a Caged Heart of the Vile Apothecary by heading to Cormond’s Workbench in Kyovashad by crafting an Uncertain Heart Cache.

However, this only gives players a small chance that the Malignant Heart that comes out of the Uncertain Heart Cache is the Caged Heart of the Vile Apothecary.

Some players have tested this themselves and have said that Wrathful Hearts are incredibly rare when it comes to these caches. This means it may not be the best place to spend your resources.

However, if you don’t have time to farm and have some spare resources laying around then it’s always worth a shot.

What Does the Caged Heart of the Vile Apothecary Do?

The Caged Heart of the Vile Apothecary is a Malignant Rogue skill that gives players a (5-15%) chance to apply all Imbuement Effects (Poison, Shadow, Cold) at 50-60% of their normal power to an enemy.

This allows players to experiment with powerful DoT (Damage Over Time) builds while also dishing out Crowd Control effects.

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Daniel is an experienced writer that covers everything from video games to anime. He enjoys playing strong narrative-driven games and hoping into survival games with friends.